RAD51AP1 antibody (AA 1-303) (Biotin)

Catalog No. ABIN8030117

This Rabbit Polyclonal antibody specifically detects RAD51AP1 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for RAD51AP1 antibody (AA 1-303) (Biotin) (ABIN8030117)

Target: RAD51AP1 (RAD51-Interacting Protein (RAD51AP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD51AP1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-RAD51AP1 Antibody (Biotin)

Binding Specificity: AA 1-303

Purpose: Anti-RAD51AP1 Antibody Biotin Conjugated

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human RAD51AP1 recombinant protein (Position: M1-K303).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for RAD51AP1

Target: RAD51AP1 (RAD51-Interacting Protein (RAD51AP1))

Alternative Name: RAD51AP1

Background:

Background: The RAD51AP1 gene encodes a protein known as RAD51-associated protein 1, which plays a crucial role in homologous recombination, a DNA repair pathway essential for maintaining genomic integrity. RAD51AP1 interacts with RAD51, a key protein involved in homologous recombination, and promotes the assembly of RAD51 nucleoprotein filaments on single-stranded DNA, facilitating the search for homologous sequences and strand exchange. This process is vital for repairing DNA double-strand breaks and stalled replication forks, as well as for meiotic recombination and telomere maintenance. Dysregulation of RAD51AP1 expression or function has been implicated in cancer development and progression, as defects in homologous recombination can lead to genomic instability and oncogenesis. Understanding the molecular mechanisms underlying RAD51AP1-mediated homologous recombination is crucial for deciphering its role in DNA repair and genome maintenance, as well as for developing targeted therapies for cancer and other diseases associated with DNA damage.

Gene Full Name: RAD51 associated protein 1

Gene ID: 10635

UniProt: Q96B01