REST antibody (AA 110-1097) (HRP)

Catalog No. ABIN8030843

This Rabbit Polyclonal antibody specifically detects REST in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for REST antibody (AA 110-1097) (HRP) (ABIN8030843)

Target: REST (RE1-Silencing Transcription Factor (REST))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This REST antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-REST Antibody (HRP)

Binding Specificity: AA 110-1097

Purpose: Anti-REST Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human REST shares 62.9%,59.6% amino acid (aa) sequence identity with mouse,rat REST,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human REST recombinant protein (Position: E110-E1097). Human REST shares 62.9% and 59.6% amino acid (aa) sequence identity with mouse and rat REST, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for REST

Target: REST (RE1-Silencing Transcription Factor (REST))

Alternative Name: REST

Background:

Background: This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described.

Gene Full Name: RE1 silencing transcription factor

Gene ID: 5978

UniProt: Q13127

Pathways: Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity