Replication Termination Factor 2 (RTF2) (AA 4-306) antibody (Biotin)

Catalog No. ABIN8031597

The Rabbit Polyclonal anti-Replication Termination Factor 2 antibody is suitable to detect Replication Termination Factor 2 in samples from Human. It has been validated for WB, ELISA and IHC.

Quick Overview for Replication Termination Factor 2 (RTF2) (AA 4-306) antibody (Biotin) (ABIN8031597)

Target: Replication Termination Factor 2 (RTF2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details

Binding Specificity: AA 4-306

Purpose: Anti-RTF2 Antibody Biotin Conjugated

Predicted Reactivity: Human RTF2 shares 87.8%,88.1% amino acid (aa) sequence identity with mouse,rat RTF2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human RTF2 recombinant protein (Position: D4-F306). Human RTF2 shares 87.8% and 88.1% amino acid (aa) sequence identity with mouse and rat RTF2, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details

Target: Replication Termination Factor 2 (RTF2)

Alternative Name: RTF2

Background:

Background: Replication termination factor 2 is a protein that in humans is encoded by the RTF2 gene. Replication Termination Factor 2, often abbreviated as RTF2, is a protein involved in the regulation and termination of DNA replication processes in eukaryotic cells. It plays a crucial role in ensuring the accurate completion of DNA synthesis during cell division by coordinating the termination of replication forks at specific sites along the DNA strands. RTF2 functions by interacting with other proteins and DNA sequences to facilitate the orderly disassembly of the replication machinery and the prevention of unnecessary re-replication of genomic regions. Its activity is tightly regulated to maintain genomic stability and fidelity, making it a key player in cell cycle control mechanisms. Studies on RTF2 have provided insights into the molecular mechanisms governing DNA replication termination and its implications for cellular function and genome maintenance.

Gene Full Name: replication termination factor 2

Gene ID: 51507

UniProt: Q9BY42