RNASEH2A antibody (AA 25-299) (Fluoro488)

Catalog No. ABIN8032317

The Rabbit Polyclonal anti-RNASEH2A antibody is suitable to detect RNASEH2A in samples from Human. It has been validated for FACS.

Quick Overview for RNASEH2A antibody (AA 25-299) (Fluoro488) (ABIN8032317)

Target: RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNASEH2A antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-RNASEH2A Antibody (Fluoro488)

Binding Specificity: AA 25-299

Purpose: Anti-Ribonuclease H2, subunit A/RNASEH2A Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Ribonuclease H2, subunit A/RNASEH2A recombinant protein (Position: R25-L299).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for RNASEH2A

Target: RNASEH2A (Ribonuclease H2, Subunit A (RNASEH2A))

Alternative Name: RNASEH2A

Background:

Background: Ribonuclease H2 subunit A, also known as RNase H2 subunit A, is an enzyme that in humans is encoded by the RNASEH2A gene. The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.

Gene Full Name: ribonuclease H2 subunit A

Gene ID: 10535

UniProt: O75792