RNF111 antibody (AA 134-994) (Fluoro594)

Catalog No. ABIN8033167

The Fluoro594-conjugated Rabbit Polyclonal anti-RNF111 antibody (ABIN8033167) specifically detects RNF111 in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for RNF111 antibody (AA 134-994) (Fluoro594) (ABIN8033167)

Target: RNF111 (Ring Finger Protein 111 (RNF111))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF111 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-RNF111 Antibody (Fluoro594)

Binding Specificity: AA 134-994

Purpose: Anti-RNF111 Antibody Fluoro594 Conjugated

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human RNF111 recombinant protein (Position: F134-S994).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for RNF111

Target: RNF111 (Ring Finger Protein 111 (RNF111))

Alternative Name: RNF111

Background:

Background: E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene. The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Gene Full Name: ring finger protein 111

Gene ID: 54778

UniProt: Q6ZNA4