RNF8 antibody (AA 3-488) (Fluoro550)

Catalog No. ABIN8033364

The Rabbit Polyclonal anti-RNF8 antibody is suitable to detect RNF8 in samples from Mouse and Rat. It has been validated for FACS.

Quick Overview for RNF8 antibody (AA 3-488) (Fluoro550) (ABIN8033364)

Target: RNF8 (Ring Finger Protein 8 (RNF8))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF8 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-RNF8 Antibody (Fluoro550)

Binding Specificity: AA 3-488

Purpose: Anti-RNF8 Antibody Fluoro550 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse RNF8 recombinant protein (Position: E3-S488).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for RNF8

Target: RNF8 (Ring Finger Protein 8 (RNF8))

Alternative Name: Rnf8

Background:

Background: E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene. The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.

Gene Full Name: ring finger protein 8

Gene ID: 58230

UniProt: Q8VC56

Pathways: Production of Molecular Mediator of Immune Response