SGCA antibody (AA 24-387) (Fluoro647)

Catalog No. ABIN8034545

This Rabbit Polyclonal antibody specifically detects SGCA in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SGCA antibody (AA 24-387) (Fluoro647) (ABIN8034545)

Target: SGCA (Sarcoglycan, alpha (50kDa Dystrophin-Associated Glycoprotein) (SGCA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGCA antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-SGCA Antibody (Fluoro647)

Binding Specificity: AA 24-387

Purpose: Anti-alpha Sarcoglycan/SGCA Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human SGCA shares 90.7% amino acid (aa) sequence identity with mouse SGCA.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SGCA recombinant protein (Position: Q24-H387). Human SGCA shares 90.7% amino acid (aa) sequence identity with mouse SGCA.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SGCA

Target: SGCA (Sarcoglycan, alpha (50kDa Dystrophin-Associated Glycoprotein) (SGCA))

Alternative Name: SGCA

Background:

Background: Alpha-sarcoglycan is a protein that in humans is encoded by the SGCA gene. This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: sarcoglycan alpha

Sequence Similarities: Belongs to the sarcoglycan alpha/epsilon family.

Gene ID: 6442

UniProt: Q16586