SEC61B antibody (AA 16-96) (Fluoro488)

Catalog No. ABIN8034990

The Rabbit Polyclonal anti-SEC61B antibody is suitable to detect SEC61B in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for SEC61B antibody (AA 16-96) (Fluoro488) (ABIN8034990)

Target: SEC61B (Sec61 beta Subunit (SEC61B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEC61B antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-SEC61B Antibody (Fluoro488)

Binding Specificity: AA 16-96

Purpose: Anti-SEC61B Antibody Fluoro488 Conjugated

Predicted Reactivity: Human SEC61B shares 98.8% amino acid (aa) sequence identity with mouse SEC61B.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SEC61B recombinant protein (Position: R16-S96). Human SEC61B shares 98.8% amino acid (aa) sequence identity with mouse SEC61B.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SEC61B

Target: SEC61B (Sec61 beta Subunit (SEC61B))

Alternative Name: SEC61B

Background:

Background: Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene. The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.

Gene Full Name: SEC61 translocon subunit beta

Gene ID: 10952

UniProt: P60468

Pathways: Protein targeting to Nucleus