Senataxin (SETX) (AA 28-2447) antibody

Catalog No. ABIN8035637

This Rabbit Polyclonal antibody specifically detects Senataxin in WB and ELISA. It exhibits reactivity toward Mouse and Rat.

Quick Overview for Senataxin (SETX) (AA 28-2447) antibody (ABIN8035637)

Target: Senataxin (SETX)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Product Details

Binding Specificity: AA 28-2447

Purpose: Anti-SETX Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Mouse SETX shares 72.8% amino acid (aa) sequence identity with humanSETX.

Characteristics: Anti-SETX Antibody. Tested in WB, ELISA applications. This antibody reacts with Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse SETX recombinant protein (Position: S28-R2447). Mouse SETX shares 72.8% amino acid (aa) sequence identity with humanSETX.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Mouse, Rat ELISA, 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details

Target: Senataxin (SETX)

Alternative Name: SETX

Background:

Background: Predicted to enable RNA binding activity, identical protein binding activity, and transcription termination site sequence-specific DNA binding activity. Acts upstream of or within circadian rhythm and termination of RNA polymerase II transcription. Predicted to be located in several cellular components, including growth cone, intercellular bridge, and nuclear lumen. Predicted to be active in nuclear body. Is expressed in cerebral cortex ventricular layer and cortical plate. Used to study amyotrophic lateral sclerosis type 4. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4 and spinocerebellar ataxia with axonal neuropathy 2. Orthologous to human SETX (senataxin).

Gene Full Name: senataxin

Molecular Weight: 303 kDa

Gene ID: 269254

UniProt: A2AKX3