SAP130 antibody (AA 309-913) (APC)

Catalog No. ABIN8037680

This Rabbit Polyclonal antibody specifically detects SAP130 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SAP130 antibody (AA 309-913) (APC) (ABIN8037680)

Target: SAP130 (Sin3A-Associated Protein, 130kDa (SAP130))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAP130 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-SAP130 Antibody (APC)

Binding Specificity: AA 309-913

Purpose: Anti-SAP130 Antibody APC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SAP130 recombinant protein (Position: H309-H913).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SAP130

Target: SAP130 (Sin3A-Associated Protein, 130kDa (SAP130))

Alternative Name: SAP130

Background:

Background: Histone deacetylase complex subunit SAP130 is an enzyme that in humans is encoded by the SAP130 gene. This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.

Gene Full Name: Sin3A associated protein 130

Gene ID: 79595

UniProt: Q9H0E3