Neurofibromin 1 antibody (AA 2701-2839) (Biotin)

Catalog No. ABIN754425

This anti-Neurofibromin 1 antibody is a Rabbit Polyclonal antibody detecting Neurofibromin 1 in ELISA, IHC (p), IHC (fro). Suitable for Human, Mouse.

Quick Overview for Neurofibromin 1 antibody (AA 2701-2839) (Biotin) (ABIN754425)

Target: Neurofibromin 1 (NF1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurofibromin 1 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Neurofibromin 1 Antibody (Biotin)

Binding Specificity: AA 2701-2839

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Neurofibromin 1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Neurofibromin 1

Target: Neurofibromin 1 (NF1)

Alternative Name: NF1

Background:

Synonyms: Neurofibromin 1, DKFZp686J1293, FLJ21220, Neurofibromatosis Noonan syndrome, Neurofibromatosis related protein NF 1, Neurofibromatosis related protein NF1, neurofibromatosis type I, Neurofibromatosis-related protein NF-1, Neurofibromin 1, Neurofibromin truncated, Neurofibromin1, NF 1, NF, NF1, NF1_HUMAN, NFNS, Type 1 Neurofibromatosis, von Recklinghausen disease neurofibromin, von Recklinghausen disease related protein VRNF, VRNF, WATS, Watson disease related protein WSS, Watson syndrome, WSS.

Background: This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008].

Gene ID: 4763

UniProt: P21359

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity