Neurofibromin 1 antibody (AA 1520-1600)

Catalog No. ABIN7216026

This Rabbit Polyclonal antibody specifically detects Neurofibromin 1 in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Neurofibromin 1 antibody (AA 1520-1600) (ABIN7216026)

Target: Neurofibromin 1 (NF1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurofibromin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Neurofibromin 1 Antibody

Binding Specificity: AA 1520-1600

Purpose: Rabbit Anti-Neurofibromin Polyclonal Antibody

Specificity: Neurofibromin Polyclonal Antibody detects endogenous levels of Neurofibromin protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Neurofibromin at AA range: 1520-1600

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Neurofibromin 1

Target: Neurofibromin 1 (NF1)

Alternative Name: Neurofibromin

Background: NF1, Neurofibromin, Neurofibromatosis-related protein NF-1NF1 product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.

Molecular Weight: 319kD

Gene ID: 4763

UniProt: P21359

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity