SPAG7 antibody (AA 1-199) (Biotin)

Catalog No. ABIN8041452

The Rabbit Polyclonal anti-SPAG7 antibody is suitable to detect SPAG7 in samples from Human, Rat and Mouse. It has been validated for WB, ELISA and IHC.

Quick Overview for SPAG7 antibody (AA 1-199) (Biotin) (ABIN8041452)

Target: SPAG7 (Sperm Associated Antigen 7 (SPAG7))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPAG7 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SPAG7 Antibody (Biotin)

Binding Specificity: AA 1-199

Purpose: Anti-SPAG7 Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SPAG7 recombinant protein (Position: M1-D199).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SPAG7

Target: SPAG7 (Sperm Associated Antigen 7 (SPAG7))

Alternative Name: SPAG7

Background:

Background: Sperm-associated antigen 7 is a protein that in humans is encoded by the SPAG7 gene. SPAG7 (sperm-associated antigen 7) is a 227 amino acid nuclear protein that contains one R3H domain and is expressed in fetal brain. The gene that encodes SPAG7 consists of approximately 8,612 bases and maps to human chromosome 17p13.2. Encoding more than 1,200 genes, chromosome 17 comprises over 2.5 % of the human genome. 2 key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is ly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, colon, prostate gland and fallopian tubes.

Gene Full Name: sperm associated antigen 7

Gene ID: 9552

UniProt: O75391