SOCS2 antibody (AA 96-198) (APC)

Catalog No. ABIN8043741

The Rabbit Polyclonal anti-SOCS2 antibody is suitable to detect SOCS2 in samples from Human and Rat. It has been validated for FACS.

Quick Overview for SOCS2 antibody (AA 96-198) (APC) (ABIN8043741)

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS2 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-SOCS2 Antibody (APC)

Binding Specificity: AA 96-198

Purpose: Anti-SOCS2 Antibody APC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human SOCS2 shares 96.1%,95.1% amino acid (aa) sequence identity with mouse,rat SOCS2,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SOCS2 recombinant protein (Position: R96-V198). Human SOCS2 shares 96.1% and 95.1% amino acid (aa) sequence identity with mouse and rat SOCS2, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SOCS2

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Alternative Name: SOCS2

Background:

Background: Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. By cytogenetic and radiation hybrid mapping, Yandava et al. (1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.

Gene Full Name: suppressor of cytokine signaling 2

Sequence Similarities: Contains 1 SH2 domain.

Gene ID: 8835

UniProt: O14508

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus