Synaptophysin antibody (N-Term) (Fluoro647)

Catalog No. ABIN8044371

The Rabbit Polyclonal anti-Synaptophysin antibody is suitable to detect Synaptophysin in samples from Human, Rat and Mouse. It has been validated for FACS.

Quick Overview for Synaptophysin antibody (N-Term) (Fluoro647) (ABIN8044371)

Target: Synaptophysin (SYP)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Synaptophysin antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-Synaptophysin Antibody (Fluoro647)

Binding Specificity: N-Term

Purpose: Anti-Synaptophysin/SYP Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: identical to the related mouse,rat sequences.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Synaptophysin, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Synaptophysin

Target: Synaptophysin (SYP)

Alternative Name: SYP

Background:

Background: SYP (Synaptophysin) is located on the short arm of X chromosome (Xp11.23-p11.22). The protein is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38 kDa. It is present inneuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors, and its ubiquity at the synapse has led to the use of synaptophysin immunostaining for quantification of synapses. Also, the protein binds cholesterol and is thought to targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR).

Gene Full Name: synaptophysin

Sequence Similarities: Belongs to the synaptophysin/synaptobrevin family.

Gene ID: 6855

UniProt: P08247

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity