SYNPO antibody (C-Term) (Fluoro488)

Catalog No. ABIN8044397

This Rabbit Polyclonal antibody specifically detects SYNPO in FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for SYNPO antibody (C-Term) (Fluoro488) (ABIN8044397)

Target: SYNPO (Synaptopodin (SYNPO))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYNPO antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-SYNPO Antibody (Fluoro488)

Binding Specificity: C-Term

Purpose: Anti-Synaptopodin/SYNPO Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related mouse sequence by one amino acid,and identical to the related rat sequence.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Synaptopodin, different from the related mouse sequence by one amino acid, and identical to the related rat sequence.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SYNPO

Target: SYNPO (Synaptopodin (SYNPO))

Alternative Name: SYNPO

Background:

Background: Synaptopodin is also known as SYNPO. The spine apparatus (SA) is a specialized form of endoplasmic reticulum (ER) that is found in a subpopulation of dendritic spines in central neurons. The SA consists of a series of stacked discs that are thought to be connected to each other and to the dendritic system of ER-tubules. The actin binding protein synaptopodin (which has originally been described in podocytes of the kidney) is an essential component of the SA. Mice that lack the gene for synaptopodin do not form a spine apparatus. The SA is believed to play a critical role in learning and memory. In summary, an important function of the spine apparatus is the regulation of plasticity at individual synapses, a process known as metaplasticity. The International Radiation Hybrid Mapping Consortium mapped the SYNPO gene to chromosome 5.

Gene Full Name: synaptopodin

Sequence Similarities: Belongs to the synaptopodin family.

Gene ID: 11346

UniProt: Q8N3V7