SNCA antibody (AA 1-135) (Fluoro550)

Catalog No. ABIN8044938

The Rabbit Polyclonal anti-SNCA antibody is suitable to detect SNCA in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for SNCA antibody (AA 1-135) (Fluoro550) (ABIN8044938)

Target: SNCA (Synuclein, alpha (SNCA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNCA antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-SNCA Antibody (Fluoro550)

Binding Specificity: AA 1-135

Purpose: Anti-Alpha Synuclein/SNCA Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Alpha Synuclein/SNCA recombinant protein (Position: M1-D135).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: SNCA

Background:

Background: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Gene Full Name: synuclein alpha

Gene ID: 6622

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity