TBC1D4 antibody (AA 1118-1298) (Fluoro488)

Catalog No. ABIN8045554

The Fluoro488-conjugated Rabbit Polyclonal anti-TBC1D4 antibody (ABIN8045554) specifically detects TBC1D4 in FACS. The antibody is reactive with Human samples.

Quick Overview for TBC1D4 antibody (AA 1118-1298) (Fluoro488) (ABIN8045554)

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D4 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-TBC1D4 Antibody (Fluoro488)

Binding Specificity: AA 1118-1298

Purpose: Anti-AS160/TBC1D4 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TBC1D4 recombinant protein (Position: K1118-P1298).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for TBC1D4

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Alternative Name: TBC1D4

Background:

Background: AS160 (Akt substrate of 160 kDa), which was originally known asTBC1 domain family member 4 (TBC1D4),is a RabGTPase-activatingproteinthat in humans is encoded by theTBC1D4gene. This gene is a member of the Tre-2/BUB2/CDC16 domain family. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion.

Gene Full Name: TBC1 domain family member 4

Gene ID: 9882

UniProt: O60343