TXNIP antibody (AA 122-152) (Biotin)

Catalog No. ABIN8046236

This Rabbit Polyclonal antibody specifically detects TXNIP in WB, ELISA and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TXNIP antibody (AA 122-152) (Biotin) (ABIN8046236)

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNIP antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-TXNIP Antibody (Biotin)

Binding Specificity: AA 122-152

Purpose: Anti-TXNIP Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human TXNIP shares 93.5% amino acid (aa) sequence identity with both mouse,rat TXNIP.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TXNIP recombinant protein (Position: D122-N152). Human TXNIP shares 93.5% amino acid (aa) sequence identity with both mouse and rat TXNIP.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TXNIP

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Alternative Name: TXNIP

Background:

Background: Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene. This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants.

Gene Full Name: thioredoxin interacting protein

Gene ID: 10628

UniProt: Q9H3M7

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome