TREX1 antibody (Middle Region) (Fluoro647)

Catalog No. ABIN8046300

The Rabbit Polyclonal anti-TREX1 antibody is suitable to detect TREX1 in samples from Human. It has been validated for FACS.

Quick Overview for TREX1 antibody (Middle Region) (Fluoro647) (ABIN8046300)

Target: TREX1 (three Prime Repair Exonuclease 1 (TREX1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TREX1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-TREX1 Antibody (Fluoro647)

Binding Specificity: Middle Region

Purpose: Anti-TREX1 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: different from the related mouse sequence by four amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human TREX1, different from the related mouse sequence by four amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for TREX1

Target: TREX1 (three Prime Repair Exonuclease 1 (TREX1))

Alternative Name: TREX1

Background:

Background: Three prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene. This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants.

Gene Full Name: three prime repair exonuclease 1

Gene ID: 11277

UniProt: Q9NSU2

Pathways: Apoptosis