Thrombopoietin antibody (AA 22-259) (Fluoro550)

Catalog No. ABIN8046349

The Fluoro550-conjugated Rabbit Polyclonal anti-Thrombopoietin antibody (ABIN8046349) specifically detects Thrombopoietin in FACS. The antibody is reactive with Rat and Mouse samples.

Quick Overview for Thrombopoietin antibody (AA 22-259) (Fluoro550) (ABIN8046349)

Target: Thrombopoietin (THPO)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thrombopoietin antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-Thrombopoietin Antibody (Fluoro550)

Binding Specificity: AA 22-259

Purpose: Anti-Thrombopoietin/Thpo Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: coli-derived mouse Thrombopoietin recombinant protein (Position: S22-H259). Mouse Thrombopoietin shares 79.3%,92.9% amino acid (aa) sequence identity with human,rat Thrombopoietin,respectively.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived mouse Thrombopoietin recombinant protein (Position: S22-H259). Mouse Thrombopoietin shares 79.3% and 92.9% amino acid (aa) sequence identity with human and rat Thrombopoietin, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Thrombopoietin

Target: Thrombopoietin (THPO)

Alternative Name: Thpo

Background:

Background: Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a protein that in humans is encoded by the THPO gene. Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.

Gene Full Name: thrombopoietin

Gene ID: 21832

UniProt: P40226

Pathways: JAK-STAT Signaling, Hormone Activity