Thrombopoietin antibody (AA 27-259) (Biotin)

Catalog No. ABIN8046357

The Rabbit Polyclonal anti-Thrombopoietin antibody is suitable to detect Thrombopoietin in samples from Rat and Mouse. It has been validated for WB, ELISA and IHC.

Quick Overview for Thrombopoietin antibody (AA 27-259) (Biotin) (ABIN8046357)

Target: Thrombopoietin (THPO)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thrombopoietin antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-Thrombopoietin Antibody (Biotin)

Binding Specificity: AA 27-259

Purpose: Anti-Thrombopoietin/THPO Antibody Biotin Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived rat Thrombopoietin recombinant protein (Position: A27-H259).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Thrombopoietin

Target: Thrombopoietin (THPO)

Alternative Name: THPO

Background:

Background: Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a protein that in humans is encoded by the THPO gene. Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.

Gene Full Name: thrombopoietin

Gene ID: 7066

UniProt: P40225

Pathways: JAK-STAT Signaling, Hormone Activity