TJP1 antibody (AA 1178-1527) (Biotin)

Catalog No. ABIN8046742

The Biotin-conjugated Mouse Monoclonal anti-TJP1 antibody (Clone 3E12) (ABIN8046742) specifically detects TJP1 in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for TJP1 antibody (AA 1178-1527) (Biotin) (ABIN8046742)

Target: TJP1 (Tight Junction Protein 1 (TJP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TJP1 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 3E12

Product Details anti-TJP1 Antibody (Biotin)

Binding Specificity: AA 1178-1527

Purpose: Anti-TJP1 Antibody (monoclonal, 3E12) Biotin Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human TJP1 shares 82% amino acid (aa) sequence identity with mouse TJP1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TJP1 recombinant protein (Position: H1178-F1527). Human TJP1 shares 82% amino acid (aa) sequence identity with mouse TJP1.

Isotype: IgG1

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TJP1

Target: TJP1 (Tight Junction Protein 1 (TJP1))

Alternative Name: TJP1

Background:

Background: Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene. This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: tight junction protein 1

UniProt: Q07157

Pathways: Carbohydrate Homeostasis, Cell-Cell Junction Organization