STING/TMEM173 antibody (C-Term) (Fluoro594)

Catalog No. ABIN8049057

The Rabbit Polyclonal anti-STING/TMEM173 antibody is suitable to detect STING/TMEM173 in samples from Human and Mouse. It has been validated for FACS.

Quick Overview for STING/TMEM173 antibody (C-Term) (Fluoro594) (ABIN8049057)

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STING/TMEM173 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-STING/TMEM173 Antibody (Fluoro594)

Binding Specificity: C-Term

Purpose: Anti-TMEM173 Antibody Fluoro594 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related mouse sequence by five amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human TMEM173, different from the related mouse sequence by five amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for STING/TMEM173

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Alternative Name: TMEM173

Background:

Background: Transmembrane protein 173 is a protein that in humans is encoded by the TMEM173 gene. This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. Also the encoded protein has been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

Gene Full Name: stimulator of interferon response cGAMP interactor 1

Sequence Similarities: Belongs to the transcription factor STAT family.

Gene ID: 340061

UniProt: Q86WV6

Pathways: Activation of Innate immune Response