TTR antibody (AA 21-147) (Fluoro488)

Catalog No. ABIN8049320

This Rabbit Polyclonal antibody specifically detects TTR in WB, IHC and IF. It exhibits reactivity toward Mouse and Rat.

Quick Overview for TTR antibody (AA 21-147) (Fluoro488) (ABIN8049320)

Target: TTR (Transthyretin (TTR))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTR antibody is conjugated to Fluoro488

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TTR Antibody (Fluoro488)

Binding Specificity: AA 21-147

Purpose: Anti-Prealbumin/TTR Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Rat Prealbumin shares 94.5% amino acid (aa) sequence identity with mouse Prealbumin.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived rat Prealbumin recombinant protein (Position: G21-N147). Rat Prealbumin shares 94.5% amino acid (aa) sequence identity with mouse Prealbumin.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat Immunofluorescence, 5 μg/mL, Mouse, Rat

Comment:

Applications are recommended based on the unconjugated antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for TTR

Target: TTR (Transthyretin (TTR))

Alternative Name: Ttr

Background:

Background: Transthyretin (TTR) is also known as prealbumin. It is mapped to chromosome region 18q11.2-q12.1. This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease.

Gene Full Name: transthyretin

Gene ID: 24856

UniProt: P02767

Pathways: Hormone Transport