CREM antibody (AA 251-361) (Biotin)

Catalog No. ABIN755364

This anti-CREM antibody is a Rabbit Polyclonal antibody detecting CREM in ELISA, IHC (fro) and IHC (p). Suitable for Human and Mouse.

Quick Overview for CREM antibody (AA 251-361) (Biotin) (ABIN755364)

Target: CREM (CAMP Responsive Element Modulator (CREM))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CREM antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CREM Antibody (Biotin)

Binding Specificity: AA 251-361

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CREM

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CREM

Target: CREM (CAMP Responsive Element Modulator (CREM))

Alternative Name: CREM

Background:

Synonyms: cAMP response element modulator, CREM-1, cAMP responsive element modulator, hCREM 2, hCREM2, ICER, Inducible cAMP early repressor, Inducible cAMP early repressor ICER, MGC111110, MGC17881, MGC41893.

Background: CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is derived from a multiexonic gene that encodes both activators and antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains and block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator.

Gene ID: 1390

UniProt: Q03060

Pathways: Retinoic Acid Receptor Signaling Pathway