p63 antibody (AA 311-680) (PE)

Catalog No. ABIN8051652

The Rabbit Polyclonal anti-p63 antibody is suitable to detect p63 in samples from Human. It has been validated for FACS.

Quick Overview for p63 antibody (AA 311-680) (PE) (ABIN8051652)

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This p63 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-p63 Antibody (PE)

Binding Specificity: AA 311-680

Purpose: Anti-p63/TP63 Antibody PE Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human p63 shares 98% amino acid (aa) sequence identity with both mouse,rat p63.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human p63 recombinant protein (Position: S311-E680). Human p63 shares 98% amino acid (aa) sequence identity with both mouse and rat p63.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for p63

Target: p63 (TP63) (Tumor Protein P63 (TP63))

Alternative Name: TP63

Background:

Background: Tumor protein p63 (TP63), also known as the p63 or TP73L is a protein that in humans is encoded by the TP63 gene. It is mapped to 3q28. TP63 is a member of the p53 family of transcription factors. This gene encodes for two main isoforms by alternative promoters (TAp63 and ΔNp63). TP63 has been mostly restricted to its apoptotic function and more recently as the guardian of oocyte integrity. It has been found that the combined loss of TP63 and p73 results in the failure of cells containing functional p53 to undergo apoptosis in response to DNA damage. TP63 is an essential regulator of stem cell maintenance in stratified epithelial tissues. Tp63 is also critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis.

Gene Full Name: tumor protein p63

Sequence Similarities: Belongs to the p53 family.

Gene ID: 8626

UniProt: Q9H3D4