TDP1 antibody (AA 1-499) (Cy3)

Catalog No. ABIN8051865

The Rabbit Polyclonal anti-TDP1 antibody is suitable to detect TDP1 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for TDP1 antibody (AA 1-499) (Cy3) (ABIN8051865)

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TDP1 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-TDP1 Antibody (Cy3)

Binding Specificity: AA 1-499

Purpose: Anti-TDP1 Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human TDP1 shares 78.8%,79.6% amino acid (aa) sequence identity with mouse,rat TDP1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TDP1 recombinant protein (Position: M1-R499). Human TDP1 shares 78.8% and 79.6% amino acid (aa) sequence identity with mouse and rat TDP1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for TDP1

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Alternative Name: TDP1

Background:

Background: The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).

Gene Full Name: tyrosyl-DNA phosphodiesterase 1

Gene ID: 55775

UniProt: Q9NUW8