Adrenomedullin antibody

Catalog No. ABIN8065421

This Mouse Monoclonal antibody specifically detects Adrenomedullin in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for Adrenomedullin antibody (ABIN8065421)

Target: Adrenomedullin (ADM)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Adrenomedullin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Clone: 1

Product Details anti-Adrenomedullin Antibody

Purpose: Anti-Adrenomedullin Antibody

Specificity: ABS 027-01 binds human adrenomedullin and shows no cross-reaction with CGRP. The epitope of ABS 027-01 lies within residues 22-52.

Predicted Reactivity: Human

Purification: Protein A or Protein G purified

Immunogen: Synthetic human adrenomedullin 1-52

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 24 months

Target Details for Adrenomedullin

Target: Adrenomedullin (ADM)

Alternative Name: Adrenomedullin

Target Type: Hormone

Background: ADM, AM, PAMP, pro-adrenomedullin, preproadrenomedullin, proadrenomedullin N-20 terminal peptide,Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:8387282, PubMed:9620797). Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. {ECO:0000269|PubMed:8387282, ECO:0000269|PubMed:9620797}., [Adrenomedullin]: Peptide hormone that act as potent hypotensive and vasodilatator agents (PubMed:8387282). ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex (PubMed:32296767, PubMed:9620797). {ECO:0000269|PubMed:32296767, ECO:0000269|PubMed:8387282, ECO:0000269|PubMed:9620797}., [Proadrenomedullin N-20 terminal peptide]: Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells (PubMed:10588445, PubMed:9578982). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:15823563). {ECO:0000269|PubMed:15823563, ECO:0000303|PubMed:10588445, ECO:0000303|PubMed:9578982}., [Proadrenomedullin 9-20 terminal peptide]: Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells (PubMed:10588445, PubMed:9578982). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:15823563, PubMed:34789875). {ECO:0000269|PubMed:15823563, ECO:0000269|PubMed:34789875, ECO:0000303|PubMed:10588445, ECO:0000303|PubMed:9578982}.,ADM,Human adrenomedullin is a 52 amino acid peptide (MW 6029) with the physiological effect of lowering blood pressure through vasodilatation, an effect it shares with calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP). In addition adrenomedullin has other cardiovascular effects including growth and development of both cardiovascular tissues and bone, and has effects in the central nervous system connected with the regulation of fluid balance.

Molecular Weight: 21 kDa (preproadrenomedullin), 6 kDa (mature peptide)

Gene ID: 133

UniProt: P35318

Pathways: Hormone Transport, Hormone Activity, C21-Steroid Hormone Metabolic Process, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Tube Formation