F12 antibody

Catalog No. ABIN8065426

The Mouse Monoclonal anti-F12 antibody (Clone 10-11-05) (ABIN8065426) specifically detects F12 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for F12 antibody (ABIN8065426)

Target: F12 (Coagulation Factor XII (F12))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This F12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Clone: 10-11-05

Product Details anti-F12 Antibody

Purpose: Anti-Factor XII (heavy chain) Antibody

Specificity: CAM 011-05 binds the heavy chain of human factor XII, including factor XII derivatives such as α-factor XIIa and α-factor XIIa C1-inhibitor complexes. Differs from CAM 011-37.

Predicted Reactivity: Human

Purification: Protein A or Protein G purified

Immunogen: Affinity purified human factor XII.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 24 months

Target Details for F12

Target: F12 (Coagulation Factor XII (F12))

Alternative Name: Factor XII

Background: F12, HAE3, HAEX, HAF, coagulation factor XII, Hageman factor, Plasma coagulation Factor XIIa, beta-factor XIIa part 1, beta-factor XIIa part 2, coagulation factor XIIa heavy chain, coagulation factor XIIa light chain,Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (PubMed:2019570, PubMed:21304106, PubMed:8427954). {ECO:0000269|PubMed:2019570, ECO:0000269|PubMed:21304106, ECO:0000269|PubMed:8427954}.,F12,Factor XII is a component in the coagulation cascade. It is a plasma glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII to a-factor XIIa, which in turn activates factor XI to factor XIa.

Molecular Weight: 50 kDa

Gene ID: 2161

UniProt: P00748

Pathways: Complement System