Adipsin antibody

Catalog No. ABIN8065441

The Mouse Monoclonal anti-Adipsin antibody (Clone D10-4) (ABIN8065441) specifically detects Adipsin in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for Adipsin antibody (ABIN8065441)

Target: Adipsin (CFD) (Complement Factor D (CFD))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Adipsin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Clone: D10-4

Product Details anti-Adipsin Antibody

Purpose: Anti-Complement Factor D Antibody

Specificity: GAU 010-04 is specific for complement factor D in human serum and plasma. Epitope specificity differs from that of GAU 008-01. (1)

Predicted Reactivity: Human

Purification: Protein A or Protein G purified

Immunogen: Human factor D

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 24 months

Target Details for Adipsin

Target: Adipsin (CFD) (Complement Factor D (CFD))

Alternative Name: Complement Factor D

Background: CFD, ADIPSIN, ADN, DF, PFD, complement factor D, C3 convertase activator, D component of complement (adipsin), complement factor D preproprotein, properdin factor D,Serine protease that initiates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:21205667, PubMed:22362762, PubMed:6769474, PubMed:874324, PubMed:9748277). In contrast to other complement pathways (classical, lectin and GZMK) that are directly activated by pathogens or antigen-antibody complexes, the alternative complement pathway is initiated by the spontaneous hydrolysis of complement C3 (PubMed:21205667, PubMed:22362762, PubMed:6769474, PubMed:874324). The alternative complement pathway acts as an amplification loop that enhances complement activation by mediating the formation of C3 and C5 convertases (PubMed:21205667, PubMed:22362762, PubMed:6769474, PubMed:874324). Activated CFD cleaves factor B (CFB) when the latter is complexed with complement C3b, activating the C3 convertase of the alternative pathway (PubMed:21205667, PubMed:6769474, PubMed:874324, PubMed:9748277). {ECO:0000269|PubMed:21205667, ECO:0000269|PubMed:22362762, ECO:0000269|PubMed:6769474, ECO:0000269|PubMed:874324, ECO:0000269|PubMed:9748277}.,CFD,Complement factor D is a serine protease of the alternative pathway of complement activation. The protein is a single chain polypeptide with a molecular mass of 25 kDa. Factor D cleaves factor B bound to C3b, generating the alternative pathway C3 convertase C3bBb and releasing the Ba fragment.

Molecular Weight: 25 kDa

Gene ID: 1675

UniProt: P00746

Pathways: Complement System