D-Dimer antibody

Catalog No. ABIN8065447

The Mouse Monoclonal anti-D-Dimer antibody (Clone 28) (ABIN8065447) specifically detects D-Dimer in ELISA and WB. The antibody is reactive with Human samples.

Quick Overview for D-Dimer antibody (ABIN8065447)

Target: D-Dimer

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This D-Dimer antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Grade: Carrier-free

Clone: 28

Product Details anti-D-Dimer Antibody

Purpose: Anti-D-Dimer Antibody

Specificity: ABS 015-28 binds human D-dimer. Cross-reacts with directly coated D-monomer but not with directly coated fibrinogen. When tested in a pair with itself, with ABS 015-22 and a fibrinogen-specific polyclonal antibody, the epitope appears to relate to the neo-epitope formed by cleavage of D-dimer from fibrin.

Predicted Reactivity: Canine,Human

Purification: Protein A or Protein G purified

Immunogen: Purified human D-dimer

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 24 months

Target Details for D-Dimer

Target: D-Dimer

Background: FGA, AMYLD2, Fib2, fibrinogen alpha chain, fibrinogen, A alpha polypeptide, FGB, HEL-S-78p, fibrinogen beta chain, beta-fibrinogen, epididymis secretory sperm binding protein Li 78p, fibrinogen, B beta polypeptide, FGG, fibrinogen gamma chain, fibrinogen, gamma polypeptide, testicular tissue protein Li 70,Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways,FGA, FGB, FGG,D-dimer is a fibrin degradation product, a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis.

Molecular Weight: 180 kDa

Gene ID: 2243, 2244, 2266

UniProt: P02671, P02675, P02679