FCN1 antibody (AA 95-314)

Catalog No. ABIN8065464

The Mouse Monoclonal anti-FCN1 antibody is suitable to detect FCN1 in samples from Human. It has been validated for ELISA.

Quick Overview for FCN1 antibody (AA 95-314) (ABIN8065464)

Target: FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FCN1 antibody is un-conjugated

Application: ELISA

Grade: Carrier-free

Clone: 5

Product Details anti-FCN1 Antibody

Binding Specificity: AA 95-314

Purpose: Anti-M-Ficolin Antibody

Specificity: ABS 036-05 reacts specifically with M-Ficolin.

Predicted Reactivity: Human

Purification: Protein A or Protein G purified

Immunogen: Recombinant human M-Ficolin (aa 95 to 314)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 24 months

Target Details for FCN1

Target: FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1))

Alternative Name: M-Ficolin

Background: FCN1, FCNM, ficolin-1, M-ficolin, ficolin (collagen/fibrinogen domain-containing) 1, ficolin-A, ficolin-alpha,Extracellular lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:16116205, PubMed:17897951, PubMed:20032467). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:16116205, PubMed:20032467). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (PubMed:20032467, PubMed:20400674). May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). {ECO:0000269|PubMed:16116205, ECO:0000269|PubMed:17897951, ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}.,FCN1,M-Ficolin (Ficolin-1) is a non-serum protein that is expressed in leukocytes and lung. M-Ficolin precipitates with mannose-binding lectin (MBL)-associated serine proteases (MASP)-1 and MASP-2, indicating that M-Ficolin forms complexes with MASP-1 and MASP-2, recognizes certain types of bacteria and subsequently activates the lectin pathway.

Molecular Weight: 35 kDa

Gene ID: 2219

UniProt: O00602

Pathways: Complement System