GLP-1 antibody (N-Term)

Catalog No. ABIN8065490

This Mouse Monoclonal antibody specifically detects GLP-1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for GLP-1 antibody (N-Term) (ABIN8065490)

Target: GLP-1 (Glucagon-like peptide 1 (GLP-1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GLP-1 antibody is un-conjugated

Application: ELISA

Grade: Carrier-free

Clone: 1E1

Product Details anti-GLP-1 Antibody

Binding Specificity: N-Term

Purpose: Anti-GLP-1 (7-37) and GLP-1 (7-36) amide (N-term) Antibody

Specificity: ABS 033-10 binds the free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide and shows <0.2 % cross-reactivity with GLP-1(9-36)amide, glucagon and human GIP. Cross-reacts 0.25 % with GLP-1(1-37), approximately 6 % with human GLP-2 and approximately 50 % with exendin-4. ABS 033-10 cross-reacts with Liraglutide.

Predicted Reactivity: Human

Purification: Protein A or Protein G purified

Immunogen: Synthetic GLP-1(7-17)

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 12 months

Target Details for GLP-1

Target: GLP-1 (Glucagon-like peptide 1 (GLP-1))

Alternative Name: GLP-1

Background: GCG, GLP-1, GLP1, GLP2, GRPP, pro-glucagon, glicentin-related polypeptide, glucagon-like peptide 1, glucagon-like peptide 2, incretin, preproglucagon,Glucagon-like peptide 1. Potent stimulator of glucose-dependent insulin release (PubMed:22037645, PubMed:40446798). Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels (PubMed:10605628, PubMed:14719035, PubMed:12554744). May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin (PubMed:10605628, PubMed:14719035, PubMed:12554744). Has growth-promoting activities on intestinal epithelium (PubMed:10605628, PubMed:14719035, PubMed:12554744). May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion (PubMed:10605628, PubMed:14719035, ubMed:12554744). Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation (PubMed:10605628, PubMed:14719035, PubMed:12554744). Inhibits beta cell apoptosis (PubMed:10605628, PubMed:14719035, PubMed:12554744).,GCG,Glucagon-like peptide 1(7-36)amide (GLP-1(7-36)amide) is the principal active form of GLP-1, the other being GLP-1(7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.

Molecular Weight: 20 kDa (proglucagon)

Gene ID: 2641

UniProt: P01275