Recombinant BCOR antibody (AA 100-400)

Catalog No. ABIN8093014

This Rabbit Monoclonal antibody specifically detects BCOR in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant BCOR antibody (AA 100-400) (ABIN8093014)

Target: BCOR (BCL6 Co-Repressor (BCOR))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BCOR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: BCOR-13087R

Product Details anti-BCOR Antibody

Binding Specificity: AA 100-400

Purpose: BCOR Antibody / BCL6 corepressor (azide and preservative free)

Purification: Protein G affinity

Immunogen: A recombinant fragment (around amino acids 100-400) of human BCOR protein (exact sequence is proprietary) was used as the immunogen for the Transcriptional Corepressor BCOR antibody.

Isotype: IgG, kappa

Application Details

Application Notes: 1. Optimal dilution of the Transcriptional Corepressor BCOR antibody should be determined by the researcher.

2. This Transcriptional Corepressor BCOR antibody is recombinantly produced by expression in human HEK293 cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Transcriptional Corepressor BCOR antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for BCOR

Target: BCOR (BCL6 Co-Repressor (BCOR))

Alternative Name: BCOR

Background: Transcriptional Corepressor BCOR antibody recognizes BCL-6 corepressor, a nuclear transcriptional regulator encoded by the BCOR gene. BCOR is a chromatin-associated protein that functions as a transcriptional corepressor and epigenetic modulator, primarily localizing to the nucleus where it participates in gene silencing complexes. As a component of noncanonical Polycomb repressive complex 1 variants, BCOR contributes to histone modification and stable transcriptional repression of lineage-specific genes.

BCOR interacts with sequence-specific transcription factors, including BCL6, to regulate gene expression programs involved in cell proliferation, differentiation, and apoptosis. Through recruitment of histone deacetylases and Polycomb group proteins, BCOR promotes chromatin condensation and transcriptional repression. These functions are critical during embryonic development, hematopoietic lineage commitment, and maintenance of cellular identity. BCOR is expressed in a range of tissues, with prominent nuclear expression in proliferative and differentiating cell populations.

The BCOR gene is located on the X chromosome and produces multiple transcript variants. Genetic alterations, mutations, and gene fusions involving BCOR have been reported in hematologic malignancies, certain sarcomas, and developmental disorders. Because of its role in epigenetic regulation and tumor biology, BCOR has become an important research target in oncology and developmental biology. Altered BCOR expression patterns may support tumor classification and molecular characterization in research settings.

This Transcriptional Corepressor BCOR antibody (clone BCOR/13087R) is suitable for detecting BCOR expression in research applications. The expected staining pattern is predominantly nuclear, consistent with its established role in transcriptional repression complexes. A Transcriptional Corepressor BCOR antibody is useful for studying chromatin remodeling, Polycomb-associated repression, hematologic malignancies, and developmental signaling pathways.

UniProt: Q6W2J9