FABP2 antibody (AA 1-132)

Catalog No. ABIN8093175

The Mouse Monoclonal anti-FABP2 antibody (Clone FABP2-6344) (ABIN8093175) specifically detects FABP2 in WB and IHC. The antibody is reactive with Human, Rat, Mouse, Guinea Pig, Hamster and Rabbit samples.

Quick Overview for FABP2 antibody (AA 1-132) (ABIN8093175)

Target: FABP2 (Fatty Acid Binding Protein 2, Intestinal (FABP2))

Reactivity: Human, Rat, Mouse, Guinea Pig, Hamster, Rabbit

Host: Mouse

Clonality: Monoclonal

Conjugate: This FABP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: FABP2-6344

Product Details anti-FABP2 Antibody

Binding Specificity: AA 1-132

Purpose: FABP2 Antibody / Fatty acid binding protein 2 (azide and preservative free)

Immunogen: A recombinant fragment (around amino acids 1-132) of human FABP2 protein (exact sequence is proprietary) was used as the immunogen for the FABP2/Fatty acid binding protein 2 antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the FABP2 Antibody / Intestinal Lipid Transport Marker should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: FABP2/Fatty acid binding protein 2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for FABP2

Target: FABP2 (Fatty Acid Binding Protein 2, Intestinal (FABP2))

Alternative Name: FABP2

Background: Intestinal fatty acid-binding protein (FABP2) is a small cytoplasmic lipid-binding protein encoded by the FABP2 gene and predominantly expressed in absorptive epithelial cells of the small intestine. FABP2 Antibody / Intestinal Lipid Transport Marker is useful for studying enterocyte biology, dietary lipid absorption, epithelial differentiation, and intestinal metabolic regulation. FABP2 belongs to the fatty acid-binding protein family, a group of structurally related intracellular proteins that bind long-chain fatty acids and facilitate their intracellular trafficking and metabolic utilization.

FABP2 antibody, also referred to as Intestinal fatty acid-binding protein antibody or I-FABP antibody in the literature, recognizes a protein that plays a major role in intestinal lipid handling and nutrient absorption. FABP2 is localized primarily within the cytoplasm of mature enterocytes lining the small intestinal villi, where it participates in fatty acid uptake, intracellular transport, and delivery of lipids to pathways involved in triglyceride synthesis and energy metabolism. Due to its highly restricted intestinal expression pattern, FABP2 is widely used as a marker of differentiated intestinal epithelium and enterocyte maturation.

FABP2 contributes to intestinal metabolic homeostasis by binding dietary fatty acids and promoting their efficient intracellular movement following luminal absorption. The protein participates in pathways associated with lipid digestion, chylomicron assembly, cellular energy regulation, and epithelial barrier maintenance. FABP2 has also been investigated in obesity, insulin resistance, inflammatory bowel disease, intestinal injury, and metabolic syndrome, reflecting the importance of intestinal lipid metabolism in systemic metabolic health.

In histologic applications, FABP2 expression is commonly observed as strong cytoplasmic staining in absorptive epithelial cells of the small intestine, particularly within villous enterocytes. This characteristic localization pattern makes FABP2 a useful marker for intestinal epithelial differentiation and gastrointestinal tissue characterization. Changes in FABP2 expression have additionally been reported in gastrointestinal malignancies and inflammatory disorders affecting intestinal epithelial integrity and absorptive function.

FABP2 is encoded on human chromosome 4q28-q31 and produces a highly conserved beta-barrel fatty acid-binding protein typical of the FABP family. The compact ligand-binding structure enables rapid intracellular fatty acid exchange and transport within enterocytes exposed to fluctuating dietary lipid levels. FABP2 functions closely with other intestinal transport and metabolic proteins involved in nutrient sensing, fatty acid uptake, and epithelial metabolic adaptation.

Clone FABP2/6344 has been evaluated using western blotting, immunohistochemistry, and HuProt microarray specificity validation methods to support selective detection of FABP2 in research applications. Western blot analysis commonly demonstrates FABP2 near its predicted molecular weight in intestinal tissue lysates, while immunohistochemistry reveals strong enterocyte-associated cytoplasmic staining patterns consistent with the known biology of this intestinal lipid transport protein. Protein microarray validation further supports specificity for FABP2 among thousands of human proteins represented on the array.

Explore our broader < a href=../metabolism-antibody-antibodies.html>Metabolism Antibodies page for additional antibodies targeting lipid transport, nutrient absorption, energy regulation, and metabolic signaling pathways across hepatic, intestinal, adipocyte, and endocrine tissues.

UniProt: P12104