Recombinant FOLR1 antibody

Catalog No. ABIN8093187

The Mouse Monoclonal anti-FOLR1 antibody (Clone rFOLR1-13324) (ABIN8093187) specifically detects FOLR1 in ELISA. The antibody is reactive with Human samples.

Quick Overview for Recombinant FOLR1 antibody (ABIN8093187)

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FOLR1 antibody is un-conjugated

Application: ELISA

Clone: RFOLR1-13324

Product Details anti-FOLR1 Antibody

Purpose: FOLR1 Antibody / Folate receptor 1

Immunogen: Recombinant human FOLR1 protein was used as the immuongen for the FOLR1/Folate receptor 1 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the FOLR1/Folate receptor 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: FOLR1/Folate receptor 1 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for FOLR1

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Alternative Name: FOLR1

Background: FOLR1 antibody is used to study Folate receptor 1, a high-affinity folate binding protein that plays a central role in cellular folate uptake and utilization. Folate receptor 1 is encoded by the FOLR1 gene and belongs to a small family of folate receptors that bind folic acid and related folates with nanomolar affinity. By concentrating folate at the cell surface, Folate receptor 1 supports metabolic pathways essential for DNA synthesis, methylation reactions, and cellular growth.

Folate receptor 1 is a glycosylphosphatidylinositol-anchored protein that localizes to the plasma membrane, where it mediates folate internalization through receptor-dependent endocytic mechanisms. This mode of transport is distinct from reduced folate carriers and proton-coupled folate transporters, allowing Folate receptor 1 to function efficiently in specific tissue environments. Studies using FOLR1 antibody have helped define the biochemical properties and trafficking behavior of this receptor within folate transport networks.

Expression of Folate receptor 1 is tightly regulated and typically restricted to select epithelial tissues, including placenta and kidney, reflecting tissue-specific folate requirements. In polarized epithelial cells, Folate receptor 1 often exhibits apical membrane localization, consistent with its role in directional nutrient uptake. Detection of Folate receptor 1 using a FOLR1 antibody supports investigation of epithelial organization, membrane specialization, and nutrient transport dynamics.

In disease-related research, altered expression of Folate receptor 1 has been examined in epithelial malignancies and conditions associated with dysregulated folate metabolism. Increased FOLR1 expression is thought to reflect heightened folate demand and metabolic adaptation rather than lineage alone. As a result, FOLR1 antibody is widely applied in studies exploring metabolic reprogramming, epithelial tumor biology, and folate-dependent cellular processes.

FOLR1 antibody (clone rFOLR1/13324) is designed to detect Folate receptor 1 in research applications. Analysis of FOLR1 expression enables evaluation of folate binding capacity, membrane-associated receptor distribution, and tissue-specific metabolic regulation. Overall, Folate receptor 1 remains a key component of folate biology and an important target for studies of epithelial physiology and disease-associated metabolic change.

UniProt: P15328

Pathways: Dicarboxylic Acid Transport