Recombinant FOLR1 antibody

Catalog No. ABIN8093189

The Rabbit Monoclonal anti-FOLR1 antibody is suitable to detect FOLR1 in samples from Human, Mouse, Rat, Guinea Pig and Hamster. It has been validated for WB and IHC.

Quick Overview for Recombinant FOLR1 antibody (ABIN8093189)

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat, Guinea Pig, Hamster

Host: Rabbit

Clonality: Monoclonal

Conjugate: This FOLR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: FOLR1-12910R

Product Details anti-FOLR1 Antibody

Purpose: FOLR1 Antibody / Folate receptor 1

Immunogen: A recombinant fragment of human FOLR1 protein (exact sequence is proprietary) was used as the immuongen for the FOLR1/Folate receptor alpha antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the FOLR1/Folate receptor alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: FOLR1/Folate receptor alpha antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for FOLR1

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Alternative Name: FOLR1

Background: Folate receptor alpha antibody is commonly used to study Folate receptor alpha, a high-affinity folate binding protein that mediates cellular folate uptake through receptor-dependent endocytosis. Folate receptor alpha is encoded by the FOLR1 gene and belongs to a specialized class of folate transporters that operate independently of reduced folate carriers. By concentrating folate at the cell surface and facilitating internalization, Folate receptor alpha supports one-carbon metabolism, nucleotide biosynthesis, and cellular proliferation in folate-dependent tissues.

Folate receptor alpha is a glycosylphosphatidylinositol-anchored protein localized primarily to the plasma membrane, where it exhibits strong affinity for oxidized folate forms. This membrane anchoring distinguishes Folate receptor alpha from transmembrane folate transporters and contributes to its polarized distribution in epithelial cells. Studies using FOLR1 antibody have been central to defining receptor localization, ligand binding behavior, and intracellular trafficking following folate uptake.

Expression of Folate receptor alpha is normally restricted to select epithelial tissues, including placenta, kidney, and certain secretory epithelia, where it localizes to the apical cell surface. This restricted expression pattern reflects tissue-specific folate requirements and epithelial polarity. In experimental systems, detection of Folate receptor alpha using a FOLR1 antibody enables investigation of epithelial differentiation, membrane organization, and nutrient transport pathways.

Dysregulated expression of Folate receptor alpha has been widely documented in epithelial malignancies, particularly those arising from tissues that normally express FOLR1 at low levels. In these contexts, increased Folate receptor alpha expression is thought to reflect altered metabolic demand and changes in folate utilization. Use of a Folate receptor alpha antibody supports research into folate metabolism, epithelial tumor biology, and membrane-associated receptor dynamics without reliance on tumor-associated antigen nomenclature.

Folate receptor alpha antibody (clone FOLR1/12910R) is designed to detect Folate receptor alpha in research applications. Assessment of FOLR1 expression and localization provides insight into folate binding capacity, membrane-associated transport mechanisms, and tissue-specific metabolic regulation. Overall, Folate receptor alpha remains a fundamental protein for studies of folate biology, epithelial physiology, and disease-associated metabolic adaptation.

UniProt: P15328

Pathways: Dicarboxylic Acid Transport