IL3RA antibody (AA 26-171)

Catalog No. ABIN8093269

This Mouse Monoclonal antibody specifically detects IL3RA in WB. It exhibits reactivity toward Human, Mouse, Rat and Hamster.

Quick Overview for IL3RA antibody (AA 26-171) (ABIN8093269)

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Reactivity: Human, Mouse, Rat, Hamster

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL3RA antibody is un-conjugated

Application: Western Blotting (WB)

Clone: IL3RA-1822

Product Details anti-IL3RA Antibody

Binding Specificity: AA 26-171

Purpose: IL3RA Antibody / Interleukin-3 receptor subunit alpha

Immunogen: A recombinant fragment of human IL3RA protein (around amino acids 26-171) (exact sequence is proprietary) was used as the immunogen for the Interleukin-3 receptor alpha chain antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Interleukin-3 receptor alpha chain antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Interleukin-3 receptor alpha chain antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for IL3RA

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Alternative Name: IL3RA

Background: Interleukin-3 receptor alpha chain antibody targets Interleukin 3 receptor alpha, a type I transmembrane cytokine receptor subunit that serves as the ligand-binding component of the interleukin-3 receptor complex. Interleukin-3 receptor alpha chain is primarily localized to the cell surface and associates with the shared beta chain to enable intracellular signaling following cytokine engagement. This receptor system plays an important role in regulating hematopoietic cell survival, proliferation, and differentiation during immune development and homeostasis.

Interleukin 3 receptor alpha chain expression is dynamically regulated across hematopoietic lineages and developmental stages. The receptor is expressed on hematopoietic stem and progenitor cells, monocytes, basophils, plasmacytoid dendritic cells, and select immune cell populations, reflecting its involvement in early immune cell specification and functional maturation. Because of this expression pattern, antibody-based detection of Interleukin 3 receptor alpha chain is widely used in research examining cytokine responsiveness, lineage commitment, and immune cell differentiation within the hematopoietic system.

Signaling through Interleukin 3 receptor alpha influences multiple intracellular pathways associated with cell survival and proliferative capacity following cytokine stimulation. These signaling events contribute to immune cell expansion and maintenance under both physiological and disease-associated conditions. Altered expression of Interleukin 3 receptor alpha chain has been reported in hematologic disorders, including myeloid neoplasms, where increased receptor expression is frequently observed on malignant cell populations. As a result, Interleukin-3 receptor alpha chain antibody reagents are commonly applied in studies investigating dysregulated cytokine signaling and immune cell abnormalities in disease models.

Beyond disease-focused research, Interleukin 3 receptor alpha chain remains relevant to broader investigations of immune activation, inflammatory signaling, and cytokine-driven cellular responses. Because receptor expression reflects cytokine sensitivity rather than antigen specificity, antibody-based detection provides insight into immune signaling potential across diverse experimental contexts. Clone IL3RA/1822 is designed to recognize Interleukin 3 receptor alpha chain and supports research applications focused on immune regulation, hematopoiesis, and cytokine receptor biology. NSJ Bioreagents offers this antibody for research use.

UniProt: P26951

Pathways: JAK-STAT Signaling