Recombinant PAX2A antibody (AA 223-354)

Catalog No. ABIN8093384

The Mouse Monoclonal anti-PAX2A antibody is suitable to detect PAX2A in samples from Human. It has been validated for IHC.

Quick Overview for Recombinant PAX2A antibody (AA 223-354) (ABIN8093384)

Target: PAX2A (Paired Box Gene 2a (PAX2A))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAX2A antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: RPAX2-8506

Product Details anti-PAX2A Antibody

Binding Specificity: AA 223-354

Purpose: PAX2 Antibody / Paired box protein Pax-2 (azide and preservative free)

Immunogen: A recombinant fragment (around amino acids 223-354) of human PAX2 protein (exact sequence is proprietary) was used as the immunogen for the Paired box protein 2/PAX2 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Paired box protein 2/PAX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Paired box protein 2/PAX2 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for PAX2A

Target: PAX2A (Paired Box Gene 2a (PAX2A))

Alternative Name: PAX2

Background: Paired box protein 2 antibody, also known as PAX2 antibody, recognizes a nuclear transcription factor commonly referred to as Paired box protein Pax-2 and Paired box gene 2. Paired box protein 2 is encoded by the PAX2 gene located on chromosome 10q24 and belongs to the paired box family of developmental regulators. The protein localizes predominantly to the nucleus, where it functions as a DNA-binding transcription factor controlling gene expression during embryogenesis and tissue differentiation. PAX2 is highly expressed during kidney, urogenital tract, eye, ear, and central nervous system development, with limited expression in most normal adult tissues.

Paired box protein 2 plays a central role in nephric duct formation, renal morphogenesis, and optic nerve development by regulating genes involved in cell proliferation, survival, and lineage specification. Through its transcriptional activity, it coordinates developmental signaling pathways including Wnt and growth factor-mediated cascades. Paired box protein 2 antibody is widely used in developmental biology and tumor research to study renal differentiation and to identify neoplasms of renal or Mullerian origin. In adult tissues, PAX2 expression can be reactivated during tissue repair or oncogenic transformation.

Structurally, Paired box protein 2 contains a conserved paired DNA-binding domain and a partial homeodomain that enable sequence-specific transcriptional regulation. It interacts with co-regulators and chromatin-modifying complexes to activate or repress target genes. Alternative splicing generates multiple isoforms that may contribute to tissue-specific regulatory functions and developmental stage-dependent expression patterns.

Dysregulated PAX2 expression is associated with tumorigenesis. Elevated nuclear PAX2 levels are frequently detected in renal cell carcinoma, Wilms tumor, ovarian carcinoma, and certain endometrial carcinomas. Its characteristic nuclear staining pattern in tumor epithelial cells makes it a valuable diagnostic biomarker in pathology. Germline mutations in PAX2 are linked to congenital anomalies of the kidney and urinary tract, highlighting its importance in organ development.

Paired box protein 2 antibody supports research in embryonic development, renal pathology, and cancer biology. Recombinant monoclonal clone rPAX2/8506 recognizes PAX2 and is suitable for detecting Paired box protein 2 expression in relevant research applications.

UniProt: Q02962

Pathways: Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation