PGAM2 antibody (N-Term)

Catalog No. ABIN8093409

The Rabbit Polyclonal anti-PGAM2 antibody (ABIN8093409) specifically detects PGAM2 in WB, IHC, IF and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PGAM2 antibody (N-Term) (ABIN8093409)

Target: PGAM2 (phosphoglycerate Mutase 2 (Muscle) (PGAM2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PGAM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-PGAM2 Antibody

Binding Specificity: N-Term

Purpose: PGAM2 Antibody / Phosphoglycerate mutase 2

Purification: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Phosphoglycerate mutase 2 was used as the immunogen for the PGAM2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PGAM2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PGAM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PGAM2

Target: PGAM2 (phosphoglycerate Mutase 2 (Muscle) (PGAM2))

Alternative Name: PGAM2

Background: PGAM2 antibody targets Phosphoglycerate mutase 2, encoded by the PGAM2 gene. Phosphoglycerate mutase 2 is a cytoplasmic enzyme that catalyzes the reversible interconversion of 3-phosphoglycerate and 2-phosphoglycerate during glycolysis. As a muscle-enriched isoform of phosphoglycerate mutase, PGAM2 plays a critical role in regulating glycolytic flux in tissues with high energetic demand.

Functionally, Phosphoglycerate mutase 2 contributes to efficient ATP production by facilitating a key step in the central glycolytic pathway. Its activity supports rapid energy generation required for muscle contraction and other energy-intensive cellular processes. A PGAM2 antibody supports studies focused on carbohydrate metabolism, glycolytic regulation, and metabolic adaptation in differentiated tissues.

PGAM2 is predominantly localized to the cytoplasm, consistent with its role in glycolysis. Although highly enriched in skeletal and cardiac muscle, PGAM2 expression can also be detected in other cell types under conditions that demand increased glycolytic activity. This distribution reflects a balance between tissue specialization and broader metabolic responsiveness.

From a disease-related perspective, altered PGAM2 expression or activity has been investigated in muscle disorders, metabolic disease, and cancer. Changes in glycolytic enzyme expression can influence cellular energy balance, proliferation, and stress tolerance. As such, Phosphoglycerate mutase 2 is frequently studied in contexts linking metabolism to disease-associated phenotypes.

At the molecular level, Phosphoglycerate mutase 2 functions as a dimeric enzyme and contains conserved catalytic residues required for phosphotransfer activity. Its apparent behavior in biochemical assays may vary depending on metabolic state and post-translational regulation without altering its primary structure. PGAM2 antibody reagents enable investigation of glycolytic enzyme regulation and cellular metabolism, with NSJ Bioreagents providing reagents intended for research use.

UniProt: P15259