PDGFD antibody (Middle Region)

Catalog No. ABIN8093414

The Rabbit Polyclonal anti-PDGFD antibody is suitable to detect PDGFD in samples from Human, Mouse and Rat. It has been validated for WB, IHC, ELISA and IP.

Quick Overview for PDGFD antibody (Middle Region) (ABIN8093414)

Target: PDGFD (Platelet Derived Growth Factor D (PDGFD))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDGFD antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Product Details anti-PDGFD Antibody

Binding Specificity: Middle Region

Purpose: PDGFD Antibody / Platelet-derived growth factor D

Purification: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Platelet-derived growth factor D was used as the immunogen for the PDGF-D antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PDGF-D antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PDGF-D antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PDGFD

Target: PDGFD (Platelet Derived Growth Factor D (PDGFD))

Alternative Name: PDGFD

Background: PDGF-D antibody targets Platelet-derived growth factor D, encoded by the PDGFD gene. Platelet-derived growth factor D is an extracellular, secreted growth factor that belongs to the PDGF family of ligands and is best understood as a paracrine regulator of mesenchymal and vascular cell behavior. Unlike many intracellular signaling nodes, PDGF-D exerts its effects from outside the cell, where ligand availability and local activation can determine when and where receptor signaling occurs.

Functionally, Platelet-derived growth factor D contributes to PDGF receptor driven pathways that shape cell motility, proliferation, and survival, particularly in stromal and vascular associated contexts. Because PDGF signaling is a major regulator of pericyte and fibroblast like responses, PDGF-D is frequently studied in models of tissue repair and remodeling where receptor activation promotes matrix associated programs. A PDGF-D antibody supports studies examining growth factor ligand dynamics, receptor activation states, and pathway crosstalk that links extracellular cues to transcriptional and phenotypic changes.

PDGF-D can be expressed in a context dependent manner, including in tissues undergoing remodeling and in disease associated microenvironments where growth factor signals become amplified. Its extracellular localization means PDGF-D may be evaluated in secretome studies, pericellular fractions, or tissue sections where stromal compartments contribute to ligand production. In vitro, apparent distribution can shift with culture density and the presence of extracellular proteases that influence ligand processing and activation.

From a disease relevance standpoint, Platelet-derived growth factor D has been linked to processes such as angiogenesis, fibroblast activation, and fibrotic progression, and it is commonly evaluated in oncology research where stromal growth factor signaling supports invasion permissive niches. In these settings, PDGF-D is often considered alongside other PDGF ligands as part of a coordinated axis that impacts vascular maturation, extracellular matrix organization, and tumor-stroma communication. These roles make PDGF-D a useful marker and mechanistic target in studies connecting growth factor signaling to tissue architecture changes.

At the molecular level, Platelet-derived growth factor D is produced as a precursor that can be modified by extracellular processing events, which can influence functional signaling output and experimental detectability across sample types. This biology emphasizes the importance of considering context when interpreting PDGF-D measurements across lysates, conditioned media, and tissue derived preparations. PDGF-D antibody reagents support research into growth factor signaling and remodeling pathways, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q9GZP0

Pathways: RTK Signaling, Platelet-derived growth Factor Receptor Signaling