PDSS2 antibody (C-Term)

Catalog No. ABIN8093423

The Rabbit Polyclonal anti-PDSS2 antibody is suitable to detect PDSS2 in samples from Human. It has been validated for WB.

Quick Overview for PDSS2 antibody (C-Term) (ABIN8093423)

Target: PDSS2 (Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 2 (PDSS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDSS2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PDSS2 Antibody

Binding Specificity: C-Term

Purpose: PDSS2 Antibody / Prenyl diphosphate synthase subunit 2

Purification: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Prenyl diphosphate synthase subunit 2 was used as the immunogen for the PDSS2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PDSS2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PDSS2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PDSS2

Target: PDSS2 (Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 2 (PDSS2))

Alternative Name: PDSS2

Background: PDSS2 antibody targets Prenyl diphosphate synthase subunit 2, encoded by the PDSS2 gene. Prenyl diphosphate synthase subunit 2 is a mitochondrial protein that functions as a core component of the decaprenyl diphosphate synthase complex, which is required for coenzyme Q (ubiquinone) biosynthesis. This enzyme complex catalyzes the elongation of polyprenyl chains that form the hydrophobic tail of coenzyme Q, a critical molecule for mitochondrial electron transport and cellular energy production.

Prenyl diphosphate synthase subunit 2 acts in concert with PDSS1 to regulate the length and synthesis of decaprenyl diphosphate, a key intermediate in ubiquinone production. Through this role, PDSS2 indirectly supports mitochondrial respiratory chain function, redox balance, and ATP generation. A PDSS2 antibody supports studies focused on mitochondrial metabolism, prenyltransferase activity, and coenzyme Q biosynthetic pathways.

PDSS2 is predominantly localized to mitochondria, consistent with its role in energy metabolism and oxidative phosphorylation. Expression has been observed in metabolically active tissues, where efficient coenzyme Q production is essential for maintaining respiratory capacity. Alterations in PDSS2 expression or function can disrupt mitochondrial electron transport efficiency and increase susceptibility to oxidative stress, highlighting its importance in cellular homeostasis.

From a disease relevance perspective, Prenyl diphosphate synthase subunit 2 has been implicated in mitochondrial disorders and kidney-related pathologies, including steroid-resistant nephrotic syndrome, where impaired coenzyme Q biosynthesis contributes to cellular dysfunction. Reduced PDSS2 activity has also been explored in cancer biology, where changes in mitochondrial metabolism and redox control influence tumor cell behavior and survival.

At the molecular level, Prenyl diphosphate synthase subunit 2 contains conserved prenyltransferase-associated domains that support isoprenoid chain elongation within the mitochondrial matrix. Its enzymatic activity and stability may be influenced by mitochondrial context and metabolic state, which can affect apparent behavior in biochemical assays. PDSS2 antibody reagents enable investigation of mitochondrial coenzyme Q biosynthesis and metabolic regulation, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q86YH6