CHD3 antibody (C-Term)

Catalog No. ABIN8097021

The Rabbit Polyclonal anti-CHD3 antibody (ABIN8097021) specifically detects CHD3 in WB. The antibody is reactive with Human samples.

Quick Overview for CHD3 antibody (C-Term) (ABIN8097021)

Target: CHD3 (Chromodomain Helicase DNA Binding Protein 3 (CHD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHD3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CHD3 Antibody

Binding Specificity: C-Term

Purpose: CHD3 Antibody - C-terminal region

Sequence: RKKRDSEEEF GSERDEYREK SESGGSEYGT GPGRKRRRKH REKKEKKTKR

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CHD3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP32459-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CHD3

Target: CHD3 (Chromodomain Helicase DNA Binding Protein 3 (CHD3))

Alternative Name: CHD3

Background:

Background Information: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Gene Name: chromodomain helicase DNA binding protein 3

Alternative Symbols: ZFH, Mi-2a, SNIBCPS, Mi2-ALPHA

Protein Name: Chromodomain-helicase-DNA-binding protein 3

Molecular Weight: 220 kDa

Gene ID: 1107

NCBI Accession: NP_005843

UniProt: Q12873