GBA2 antibody (Middle Region)

Catalog No. ABIN8101560

The Rabbit Polyclonal anti-GBA2 antibody (ABIN8101560) specifically detects GBA2 in WB. The antibody is reactive with Human samples.

Quick Overview for GBA2 antibody (Middle Region) (ABIN8101560)

Target: GBA2 (Glucosidase, beta (Bile Acid) 2 (GBA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GBA2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GBA2 Antibody

Binding Specificity: Middle Region

Purpose: GBA2 Antibody - middle region

Sequence: GTVWLEVLED SLPEELGRNM CHLRPTLRDY GRFGYLEGQE YRMYNTYDVH

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GBA2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57499-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GBA2

Target: GBA2 (Glucosidase, beta (Bile Acid) 2 (GBA2))

Alternative Name: GBA2

Background:

Background Information: This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.

Gene Name: glucosylceramidase beta 2

Alternative Symbols: AD035, SPG46, NLGase

Protein Name: Non-lysosomal glucosylceramidase

Molecular Weight: 105 kDa

Gene ID: 57704

NCBI Accession: NP_065995

UniProt: Q9HCG7