Inversin antibody (C-Term)

Catalog No. ABIN8103446

The Rabbit Polyclonal anti-Inversin antibody is suitable to detect Inversin in samples from Human. It has been validated for WB.

Quick Overview for Inversin antibody (C-Term) (ABIN8103446)

Target: Inversin (INVS)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Inversin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Inversin Antibody

Binding Specificity: C-Term

Purpose: INVS Antibody - C-terminal region

Sequence: ALLKAGADVN KTDHSQRTAL HLAAQKGNYR FMKLLLTRRA NWMQKDLEEM

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 93%, Zebrafish: 86%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human INVS

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63318-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Inversin

Target: Inversin (INVS)

Alternative Name: INVS

Background:

Background Information: This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Gene Name: inversin

Alternative Symbols: INV, NPH2, NPHP2

Protein Name: Inversin

Molecular Weight: 117 kDa

Gene ID: 27130

NCBI Accession: NP_055240

UniProt: Q9Y283