MARCH11 antibody (C-Term)

Catalog No. ABIN8105161

This Rabbit Polyclonal antibody specifically detects MARCH11 in WB. It exhibits reactivity toward Human.

Quick Overview for MARCH11 antibody (C-Term) (ABIN8105161)

Target: MARCH11 (Membrane-Associated Ring Finger (C3HC4) 11 (MARCH11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MARCH11 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MARCH11 Antibody

Binding Specificity: C-Term

Purpose: MARCH11 Antibody - C-terminal region

Sequence: RVFKRWRAVN LHWDVLNYDK ATDIEESSRG ESSTSRTLWL PLTALRNRNL

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MARHB

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43511-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MARCH11

Target: MARCH11 (Membrane-Associated Ring Finger (C3HC4) 11 (MARCH11))

Alternative Name: MARCH11

Background:

Background Information: MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]

Gene Name: membrane associated ring-CH-type finger 11

Alternative Symbols: RNF226, MARCH11, MARCH-XI

Protein Name: E3 ubiquitin-protein ligase MARCH11

Molecular Weight: 44kDa

Gene ID: 441061

NCBI Accession: NP_001096032

UniProt: A6NNE9