NRF2 antibody (N-Term)

Catalog No. ABIN8106688

This Rabbit Polyclonal antibody specifically detects NRF2 in WB. It exhibits reactivity toward Human.

Quick Overview for NRF2 antibody (N-Term) (ABIN8106688)

Target: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NRF2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NRF2 Antibody

Binding Specificity: N-Term

Purpose: NFE2L2 Antibody - N-terminal region

Sequence: DILWRQDIDL GVSREVFDFS QRRKEYELEK QKKLEKERQE QLQKEQEKAF

Predicted Reactivity: Cow: 86%, Dog: 93%, Human: 100%, Mouse: 86%, Pig: 86%, Rabbit: 92%, Rat: 93%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NFE2L2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38744-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for NRF2

Target: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Alternative Name: NFE2L2

Background:

Background Information: This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters, many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene.

Gene Name: nuclear factor, erythroid 2 like 2

Alternative Symbols: NRF2, HEBP1, Nrf-2, IMDDHH

Protein Name: nuclear factor erythroid 2-related factor 2

Molecular Weight: 66 kDa

Gene ID: 4780

NCBI Accession: NP_006155

UniProt: Q16236

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling