PRDM12 antibody (C-Term)

Catalog No. ABIN8108788

This Rabbit Polyclonal antibody specifically detects PRDM12 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Pig, Guinea Pig and Rabbit.

Quick Overview for PRDM12 antibody (C-Term) (ABIN8108788)

Target: PRDM12 (PR Domain Containing 12 (PRDM12))

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PRDM12 Antibody

Binding Specificity: C-Term

Purpose: PRDM12 Antibody - C-terminal region

Sequence: IPGVPGLEED QKKNKHEDFH PADSAAGPAG RMRCVICHRG FNSRSNLRSH

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 86%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PRD12

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33217-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PRDM12

Target: PRDM12 (PR Domain Containing 12 (PRDM12))

Alternative Name: PRDM12

Background:

Background Information: This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia.

Gene Name: PR/SET domain 12

Alternative Symbols: PFM9, HSAN8

Protein Name: PR domain zinc finger protein 12

Molecular Weight: 40kDa

Gene ID: 59335

NCBI Accession: NP_067632

UniProt: Q9H4Q4