PRR5 antibody (Middle Region)

Catalog No. ABIN8108998

This Rabbit Polyclonal antibody specifically detects PRR5 in WB. It exhibits reactivity toward Human.

Quick Overview for PRR5 antibody (Middle Region) (ABIN8108998)

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRR5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PRR5 Antibody

Binding Specificity: Middle Region

Purpose: PRR5 Antibody - middle region

Sequence: TLVQKVVSPY LGTYGLHSSE GPFTHSCILE KRLLRRSRSG DVLAKNPVVR

Predicted Reactivity: Cow: 86%, Dog: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 100%, Rat: 93%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PPR5

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58943-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PRR5

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Alternative Name: PRR5

Background:

Background Information: This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.

Gene Name: proline rich 5

Alternative Symbols: PP610, PROTOR1, PROTOR-1, FLJ20185k

Protein Name: proline-rich protein 5

Molecular Weight: 31 kDa

Gene ID: 55615

UniProt: P85299

Pathways: PI3K-Akt Signaling